Vismodegib as eye-sparing adjuvant treatment for orbital basal cell carcinoma.

1). If these lesions were at the level of the RPE, one would expect themtobevisualizedonFAFimaging.However, theywere completely silent on FAF imaging, suggesting that they may be located deeper than the RPE, at the level of the choriocapillaris.Wedistinguished 3 types of lesions basedon theirmultimodal imaging characteristics in APMPPE. Type 1 lesions seem to be located at the level of the choriocapillaris and are transient. Type 2 and 3 lesions are at the level of the RPE and are permanent. Thepigmented lesionswere distributed along the choroidal vasculature on AO imaging (Figure 2). They may correspond topigment-ladenmacrophagesor accumulationof pigment granules and may indicate a secondary reaction at the levelof theRPEinducedbyan inflammatoryprocessat the level of thechoroidalvasculature.Their sizeandshapewerenotconsistent with RPE cells. Acute posterior multifocal placoid pigment epitheliopathy is characterized by prominent RPE changes, but the permanent RPE damage (type 2 and 3 lesions) may be secondary to an acute transient choroidal inflammatory process (type 1 lesions).